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Proteus Structure Prediction Server
Comprehensive Secondary Structure Predictions
 
 
 
Proteus prediction (ID=5689539) complete
Summary:
 
  • Time of Submission: 21:34:16 Apr 01, 2006
  • Sequence Name:
  • Number of residues read in: 844
  • Number of useable PDB homologs found: 12
    • 1F5XA, e-value = 1.0E-105 NMR STRUCTURE OF THE Y174 AUTOINHIBITED DBL HOMOLOGY DOMAIN
    • 2CRHA, e-value = 5.0E-65 SOLUTION STRUCTURE OF THE SH2 DOMAIN OF HUMAN PROTO-
    • 1GCPA, e-value = 8.0E-34 CRYSTAL STRUCTURE OF VAV SH3 DOMAIN
    • 1TXDA, e-value = 6.0E-17 CRYSTAL STRUCTURE OF THE DH/PH DOMAINS OF LEUKEMIA-
    • 1XCGA, e-value = 2.0E-13 CRYSTAL STRUCTURE OF HUMAN RHOA IN COMPLEX WITH DH/PH
    • 1KZ7A, e-value = 7.0E-12 CRYSTAL STRUCTURE OF THE DH/PH FRAGMENT OF MURINE DBS IN
    • 1FOEA, e-value = 5.0E-11 CRYSTAL STRUCTURE OF RAC1 IN COMPLEX WITH THE GUANINE
    • 1KI1B, e-value = 1.0E-9 GUANINE NUCLEOTIDE EXCHANGE REGION OF INTERSECTIN IN
    • 1UJYA, e-value = 7.0E-9 SOLUTION STRUCTURE OF SH3 DOMAIN IN RAC/CDC42 GUANINE
    • 1AZEA, e-value = 1.0E-8 NMR STRUCTURE OF THE COMPLEX BETWEEN THE C32S-Y7V MUTANT OF
    • 1UFFA, e-value = 5.0E-8 SOLUTION STRUCTURE OF THE FIRST SH3 DOMAIN OF HUMAN
    • 1OOTA, e-value = 6.0E-8 CRYSTAL STRUCTURE OF THE SH3 DOMAIN FROM A S. CEREVISIAE
  • Number of sequence alignments used for ab-initio predictions: 49
  • Overall confidence value: 83.4%
  • Predicted % Helix content: 37 % (313 residues)
  • Predicted % Beta sheet content: 14 % (115 residues)
  • Predicted % Coil content: 49 % (416 residues)
Graphical Alignment of PDB Homologs:

Conserved Domains
Legend:
  H = Helix
E = Beta Strand
C = Coil
Line 1 = sequence (single letter IUPAC code, 60 characters per line)
Line 2 = secondary structure (H, E or C)
Line 3 = confidence score (0-9, 0 = low, 9 = high)

A '*' character above the overall prediction indicates the homolog's structure was used at this residue.

Predicted Secondary Structure:
 
   1                                                               60
      MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNLLPHAINLREV
     
CCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCC
      985899999987635677777887776589999999984679999999758898776545

  61                                                               120
      NLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPI
     
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHCCCHHHHHHHHHHHHCCCC
      788775799999999999999999857765654787578855666899999999866777

 121                                                  ************ 180
      AQNRGIMPFPTEEESVGDEDIYSGLSDQIDDTVEEDEDLYDCVENEEAEGDEIYEDLMRS
     
CCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCC
      667777777667777777556555787777766667888766666677899999999999

 181  ************************************************************ 240
      EPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINI
     
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHCCH
      988999999999999999999999999999999999999999999999999999999999

 241  ************************************************************ 300
      EDLLRVHTHFLKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA
     
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
      999999999999999999999999999999999999999999999999999999999999

 301  ************************************************************ 360
      REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEAMEKENLRLAL
     
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
      999999999999999999999999999999999999999999999999999999999999

 361  ************************************************************ 420
      DAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHYGRPKIDGELKITSVERRSKM
     
HHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHCCCEEECCCCCCCCCCCEEE
      999999999999999777999999788999998877778998777677778899999998

 421  ************************************************************ 480
      DRYAFLLDKALLICKRRGDSYDLKDFVNLHSFQVRDDSSGDRDNKKWSHMFLLIEDQGAQ
     
EEEEEEECCEEEEEEEECCEEEECCCEECCEEEEEEECCCEECCCCCCEEEEEECCCCEE
      788988999899999887977778879757788887789877878777779999789999

 481  ********************************************************     540
      GYELFFKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTF
     
EEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCCHHHHHCC
      999898778888899899987887788668777777656766788655666653555456

 541                                                         ***** 600
      YQGYRCHRCRASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF
     
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
      677787777777777666666777778887777776667777766666777776599999

 601  ************************************************************ 660
      QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWFPCNRVKPYVH
     
EEECCCCCCCCCCCEEEEEECCEEEEEEEECCCCCCCEEEEECCCEEEEECCCCEEEECC
      999999999999999999999999999999999999999999999999999999999999

 661   *********************************************************** 720
      GPPQDLSVHLWYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKI
     
CCCCCCCCCCEEECCCCHHHHHHHHCCCCCCEEEEEEECCCCEEEEEEEEECCEEEEEEE
      799999999999999999999999999999999999999999999999999999999999

 721  ************************************************************ 780
      MTAEGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEKRTISRPAVGS
     
EECCCEEECCCCCCCCCHHHHHHHHHCCEEECCCCCEEEEEEEEECCCCCCCCCCCCCCC
      999999999999999999999999999999999999999999999999999999988778

 781  ***   ****************************************************** 840
      TKYFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPANYVEED
     
CCEEEEEEEEEEEECCCCCEEEEEEEEEEEEEEECCCCCEEEEECCCCCCEEEEEEEEEC
      887589788999998888889999999999999988899999888889999999999987

 841       844
      YSEY
     
CCCC
      7777



    Proteus uses a "Jury of Experts" approach involving predictions from PSIPRED ( Jones, 1999 ), JNET ( Barton et al., 1999 ), TRANSSEC (a locally developed tool), and structural alignment ( XALIGN ). Following is the predicted secondary structure from each component.
Detailed Prediction Information:
 

PSIPRED
   1  MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNLLPHAINLREV 60
     
CCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCEE
      988999999999877767887778997888999999878949999998758998676545

  61  NLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPI 120
     
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHCCCCHHHHHHHHHHHHCCCC
      799985699999999999999999858986684675565447889999999985555564

 121  AQNRGIMPFPTEEESVGDEDIYSGLSDQIDDTVEEDEDLYDCVENEEAEGDEIYEDLMRS 180
     
CCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCHHHCCC
      468988767788788885667755577766555647766677888888887786665788

 181  EPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINI 240
     
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCH
      777788877589999999999999999999999999999889999866989999875797

 241  EDLLRVHTHFLKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA 300
     
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
      899999999999999998688744599999998788778999996556899999999874

 301  REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEAMEKENLRLAL 360
     
CHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
      789999999997665688887687777898998666999999998599985689999999

 361  DAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHYGRPKIDGELKITSVERRSKM 420
     
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCEEEEECCCCCCC
      999999999999999999999999999986787876444664789755789876889886

 421  DRYAFLLDKALLICKRRGDSYDLKDFVNLHSFQVRDDSSGDRDNKKWSHMFLLIEDQGAQ 480
     
CEEEEEECCEEEEEECCCCCCEECCEEECCCEEEEECCCCCCCCCCCCCEEEEEECCCCE
      568998548689986689975667578658756865888866666777569998579986

 481  GYELFFKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTF 540
     
EEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCEECCCCCHHHHHCC
      899997998999999999999999986567888887665765787633345776777555

 541  YQGYRCHRCRASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF 600
     
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
      777555567776676777678988777887777777776777778787777887654455

 601  QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWFPCNRVKPYVH 660
     
HHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCCCC
      665446888888888666789978999867899876467776878777767665554566

 661  GPPQDLSVHLWYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKI 720
     
CCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCEECCCCCCCCCCEEEEEEECCCEEEEEE
      655455567888889998999998768999766664366899867999985896556688

 721  MTAEGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEKRTISRPAVGS 780
     
EECCCCEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCC
      748986785886555996887565555566655455544444444554555556566655

 781  TKYFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPANYVEED 840
     
CCCCEEEEEECCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEEECCEEEEEECHHCCCC
      555647888657688998775658888899987579988489899895988545544557

 841  YSEY 844
     
CCCC
      8899



JNET
   1  MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNLLPHAINLREV 60
     
CCHHHHHHHHEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCC
      258887722113541168899988887238999999727716899998113688777655

  61  NLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPI 120
     
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHHCCCCCC
      599998489999999999988877515998651331113303742789998863678767

 121  AQNRGIMPFPTEEESVGDEDIYSGLSDQIDDTVEEDEDLYDCVENEEAEGDEIYEDLMRS 180
     
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
      566998766679999898875567888888877888887777889999999886667779

 181  EPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINI 240
     
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCC
      999999987367888899999988889999999999987742146506434225431464

 241  EDLLRVHTHFLKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA 300
     
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHCC
      688999999999999982678852233788887333441688861441688899998726

 301  REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEAMEKENLRLAL 360
     
CHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
      437999999998235788765520111103332378999999983367887558999999

 361  DAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHYGRPKIDGELKITSVERRSKM 420
     
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCEEEECCCCCCC
      999999999989999999999999999987278875103772034115146624789876

 421  DRYAFLLDKALLICKRRGDSYDLKDFVNLHSFQVRDDSSGDRDNKKWSHMFLLIEDQGAQ 480
     
CEEEEECCCCEEEEECCCCCCEEEEEEECCCEEEEECCCCCCCCCCCCCEEEEEECCCCC
      234552242124541478874131213213137872899999998886148888468872

 481  GYELFFKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTF 540
     
EEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
      688872873578899999999999985299999998751125678532346653012303

 541  YQGYRCHRCRASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF 600
     
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCE
      578510147868766888778997777777788998888876777779999999875311

 601  QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWFPCNRVKPYVH 660
     
EEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCEEEECCCCCCCCCCCCCCECCCCC
      344430996778888775557733788848988982466518899889988762104678

 661  GPPQDLSVHLWYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKI 720
     
CCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCCEEEEEECCCCCEEEEE
      888899883010888866888886347899806776378788716888844898257888

 721  MTAEGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEKRTISRPAVGS 780
     
EECCCCEEECCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
      726775264073512683046542122567655786543334777777677787777787

 781  TKYFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPANYVEED 840
     
CCCCEEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEECCCCCEEEECCCCEEEC
      755325777557567799931004981378884269976068500883046238763518

 841  YSEY 844
     
CCCC
      9999



TRANSSEC
   1  MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNLLPHAINLREV 60
     
CCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHC
      988755664677777668888877754899999998888999999887655676655555

  61  NLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPI 120
     
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHH
      665589999999888889989999867887554455565888658855788889999999

 121  AQNRGIMPFPTEEESVGDEDIYSGLSDQIDDTVEEDEDLYDCVENEEAEGDEIYEDLMRS 180
     
HHCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHH
      877998788888888888764444666544578986544455543346886489998766

 181  EPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINI 240
     
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHCCCCHHHHHHHH
      545788888755799999999999998864576799976557778875677478999999

 241  EDLLRVHTHFLKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA 300
     
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
      889999989999999987588878999999998988999988765578999999999899

 301  REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEAMEKENLRLAL 360
     
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
      999999999999987588878999999888888888899999887656756899999999

 361  DAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHYGRPKIDGELKITSVERRSKM 420
     
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
      888889989998867886789999999988899999875677788877666546899999

 421  DRYAFLLDKALLICKRRGDSYDLKDFVNLHSFQVRDDSSGDRDNKKWSHMFLLIEDQGAQ 480
     
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
      999988999999999875885689998887546788888765679999888788875786

 481  GYELFFKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTF 540
     
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHH
      899999998888899999998887668888876655535665354466667789999999

 541  YQGYRCHRCRASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF 600
     
HHCCCCCCCCHHHCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
      865666566556545555543445545565455666655566777766556645666655

 601  QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWFPCNRVKPYVH 660
     
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
      665356556788777766677888999887656645565444555554566554455554

 661  GPPQDLSVHLWYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKI 720
     
HHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEECCCCCCEEEE
      444557778988756764567888775577655765467887653544443566645554

 721  MTAEGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEKRTISRPAVGS 780
     
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCC
      456554445554444556677777777777667646777567766788776655444456

 781  TKYFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPANYVEED 840
     
CCCCHHHHHHCCCCCCCCCHHHHCCCCEEEEEECCCCCCCEEECCCCCCEEECCCCCCCC
      665433345433677665556764886577776445676445446776556545545678

 841  YSEY 844
     
CCHH
      7557



JURY-OF-EXPERTS PREDICTION
   1  MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNLLPHAINLREV 60
     
CCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCC
      985899999987635677777887776589999999984679999999758898776545

  61  NLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPI 120
     
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHCCCHHHHHHHHHHHHCCCC
      788775799999999999999999857765654787578855666899999999866777

 121  AQNRGIMPFPTEEESVGDEDIYSGLSDQIDDTVEEDEDLYDCVENEEAEGDEIYEDLMRS 180
     
CCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
      667777777667777777556555787777766667888766666677887766555566

 181  EPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINI 240
     
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
      667788887589999999999999999999999999999999999985645699988557

 241  EDLLRVHTHFLKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA 300
     
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
      999999999999999998678667789999999998889999999989999999999997

 301  REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEAMEKENLRLAL 360
     
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
      489999999999667788764677788889999999999999999779888679999999

 361  DAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHYGRPKIDGELKITSVERRSKM 420
     
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCEEEEECCCCCCC
      999999999999999999999999999998477776666875888677679985788876

 421  DRYAFLLDKALLICKRRGDSYDLKDFVNLHSFQVRDDSSGDRDNKKWSHMFLLIEDQGAQ 480
     
EEEEEEECCEEEEEEECCCCCEEEEEEECCCEEEEECCCCCCCCCCCCEEEEEEECCCCE
      799999688789999589984877989758668997789876777777699999869988

 481  GYELFFKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTF 540
     
EEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCCHHHHHCC
      999997668999999999999999988668777777656766788655666653555456

 541  YQGYRCHRCRASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF 600
     
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
      677787777777777666666777778887777776667777766666777776546789

 601  QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWFPCNRVKPYVH 660
     
HHHCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCCC
      976478888777666667778779999966898876889985666566777887778888

 661  GPPQDLSVHLWYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKI 720
     
CCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCEEEEEEECCCCCEEEEE
      776667776667777758999999858889847755578888868999995999579999

 721  MTAEGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEKRTISRPAVGS 780
     
EECCCCEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCC
      978996898577776656899999865888766777776465566567788777777788

 781  TKYFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPANYVEED 840
     
CCCEEEEEEEECCCCCCCCCCCCCCCEEEEEEEECCCCCEEEEECCCEEEEEECCCCCCC
      888589999857787887766677877999999789986899976886899948877777

 841  YSEY 844
     
CCCC
      7777

3D-TO-2D MAPPING FOR TOP-SCORING HOMOLOG:

QUERY MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNLLPHAINLREV 60
1F5XA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
2CRHA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1GCPA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1TXDA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1XCGA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1KZ7A ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1FOEA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1KI1B ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1UJYA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1AZEA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1UFFA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1OOTA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~


  61  NLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPI 120
1F5XA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
2CRHA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1GCPA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1TXDA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1XCGA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1KZ7A ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1FOEA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1KI1B ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1UJYA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1AZEA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1UFFA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1OOTA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~


 121  AQNRGIMPFPTEEESVGDEDIYSGLSDQIDDTVEEDEDLYDCVENEEAEGDEIYEDLMRS 180
1F5XA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~KGDEIYEDLMRL
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~HHHHHHHHCCCC
2CRHA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1GCPA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1TXDA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1XCGA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1KZ7A ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1FOEA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1KI1B ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1UJYA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1AZEA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1UFFA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1OOTA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~


 181  EPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFL---KPL--QR--FLK--P- 230
1F5XA ESVPTPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFM---KPL--QR--FLK--P-
      CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH~~~HHH~~HH~~CCC~~H~
2CRHA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1GCPA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1TXDA ~~~~~~~~~~~~~KRQEVINELFYTERAHVRTLKVLDQVFY---QRV--SREGILS--P-
      ~~~~~~~~~~~~~HHHHHHHHHHHHHHHHHHHHHHHHHHHH~~~HHH~~HHHCCCC~~H~
1XCGA ~~~~~~~~~~~~~~~~~~INELFVTEASHLRTLRVLDLIFY---QRM--KKENLMP--R-
      ~~~~~~~~~~~~~~~~~~HHHHHHHHHHHHHHHHHHHHHHH~~~HHH~~HCCCCCC~~H~
1KZ7A ~~~~~~~~~~~~~~~~~~VNELLDTERAYVEELLCVLEGYAAEDNPL--AH--LIS--TG
      ~~~~~~~~~~~~~~~~~~CCHHHHHHHHHHHHHHHHHHHCCCCCCCC~~CC~~CCC~~HH
1FOEA ~~~~~~~QLSDADKLRKVICELLETERTYVKDLNCLER-YL---KPL--QKETFLT--Q-
      ~~~~~~~CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC~HH~~~HHH~~HCCCCCC~~H~
1KI1B ~~~~~~~~~~~~~KRQGYIHELIVTEENYVNDLQLVTEIFQ---KPLMESE--LLT--E-
      ~~~~~~~~~~~~~HHHHHHHHHHHHHHHHHHHHHHHHHHHH~~~HHHHHHC~~CCC~~H~
1UJYA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1AZEA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1UFFA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1OOTA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~


 230  -QDIE----IIFINIEDLLRVHTH-FLKEMKEALG-T-PG----AANLYQV--------- 269
1F5XA -QDME----TIFVNIEELFSVHTH-FLKELKDALA-G-PG----ATTLYQV---------
      ~HHHH~~~~HHHCCHHHHHHHHHH~HHHHHHHHHH~C~CC~~~~HHHHHHH~~~~~~~~~
2CRHA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1GCPA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1TXDA -SELR----KIFSNLEDILQLHIG-LNEQMKAVRK-R-NE----TSVIDQIGEDLLTW--
      ~HHHH~~~~HHHCHHHHHHHHHHH~HHHHHHHHHH~H~CC~~~~CCCCCCCHHHHHHH~~
1XCGA -EELA----RLFPNLPELIEIHNS-WCEAMKKLRE-EGPI----IKEISDL---------
      ~HHHH~~~~HHCCCHHHHHHHHHH~HHHHHHHHHH~CCCC~~~~CCCCHHH~~~~~~~~~
1KZ7A LQNKK----NILFGNEEIYHFHNRIFLRELESCID-C-PE----LVG--RC---------
      HHHHH~~~~HHHHCCCHHHHHHHHCHHHHHHHCCC~C~CC~~~~CHH~~HH~~~~~~~~~
1FOEA -DELD----VLFGNLTEV-EFQVE-FLKTLEDGVRLV-PD----LEKLEKVDQFKKVLFS
      ~HHHH~~~~HHHCCCCCC~HHHHH~HHHHHHHHHHHC~CC~~~~CCCCCCHHHHHHHHHH
1KI1B -KEVA----MIFVNWKELIMCNIK-LLKALRVRKK-M-SGEKMPVKMIGDI---------
      ~HHHH~~~~HHHCCHHHHHHHHHH~HHHHHHHHHH~H~HCCCCCCCCCHHH~~~~~~~~~
1UJYA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1AZEA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1UFFA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1OOTA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~


 269  ----FIKY------KERFLVYGR--YC-SQVESASKHLDRVAAAREDVQMK--LEECSQR 314
1F5XA ----FIKY------KERFLVYGR--YC-SQVESASKHLDQVATAREDVQMK--LEECSQR
      ~~~~HHHH~~~~~~HHHHHHHHH~~HH~HHHHHHHHHHHHHHHHHHHHHHH~~HHHHHHH
2CRHA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1GCPA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1TXDA ----FSGP------GEEKLKHAAATFC-SNQPFALEMIKSRQKKDSRFQTF--VQDAESN
      ~~~~CCCH~~~~~~HHHHHHHHHHHHH~HHHHHHHHHHHHHHHCCHHHHHH~~HHHHHHC
1XCGA ----MLARFDGPAREELQQVAAQ--FC-SYQSIALELIKTKQRKESRFQLF--MQEAESH
      ~~~~HHHCCCCHHHHHHHHHHHH~~HH~CCHHHHHHHHHHHHHHCHHHHHH~~HHHHHHC
1KZ7A ----FLE-------REEFQIYEK--YC--QNKPRSESLWRQCSDCPFFQ------ECQKK
      ~~~~HHH~~~~~~~CCHHHHHHH~~HH~~HHHHHHHHHHHHCCCCHHHH~~~~~~HHHHH
1FOEA LGGSFLYY------ADRFKLYSA--FC-ASHTKVPKVLVK---AKTDTAFKAFLDAQNPR
      HHHHHHHH~~~~~~HHHHHHHHH~~HH~HHHHHHHHHHHH~~~HHHHHHHHHHHHHHCCC
1KI1B ----LSAQ------LPHMQPYIR--FC-SRQLNGAALIQQKTDEAPDFKEF--VKRLEMD
      ~~~~HHHH~~~~~~HHCCCHHHH~~HH~HHHHHHHHHHHHHHHHCHHHHHH~~HHHHHHC
1UJYA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1AZEA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1UFFA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1OOTA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~


 315  ANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQ-E-AMEKENLRLALDAMRDLAQCVNE 372
1F5XA ANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQ-D-ATEKENLRLALDAMRDLAQCVNE
      CCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC~C~CHHHHHHHHHHHHHHHHHHHHCC
2CRHA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1GCPA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1TXDA PLCRRLQLKDIIPTQMQRLTKYPLLLDNIAKYTE-W-PTEREKVKKAADHCRQILNFVNQ
      CCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCC~C~HHHHHHHHHHHHHHHHHHHHHHH
1XCGA PQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGG-TSEHEKLCRARDQCREILKYVNE
      CCCCCCCHHHHCCHHHHHHHHHHHHHHHHHCCEEEC~CHHHHHHHHHHHHHHHHHHHHHH
1KZ7A LDH-KLSLDSYLLKPVQRITKYQLLLKEL-KYSK-H-CEGAEDLQEALSSILGILKAVND
      HCC~CCCHHHHCCHHHHHHCCHHHHHHCC~CCCC~C~CCCHHHHHHHHHHHHHHHHHHHH
1FOEA QQHSS-TLESYLIKPIQRVLKYPLLLRELFALTDAE-SEEHYHLDVAIKTNK-VASHINE
      CCCCC~CHHHHCCHHHHHHHHHHHHHHHHHHCCCCC~CHHHHHHHHHHHCCH~HHHHHHC
1KI1B PRCKGMPLSSFILKPMQRVTRYPLIIKNILENTP-ENHPDHSHLKHALEKAEELCSQVNE
      CCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHCCC~CCCCHHHHHHHHHHHHHHHHHHHHH
1UJYA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1AZEA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1UFFA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1OOTA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~


 373  VKRDNETLRQITNFQ--LSI--ENLDQSLAHYG---RPKIDGELKITS----VER----- 416
1F5XA VKR~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      CCC~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
2CRHA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1GCPA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1TXDA AVKEAENKQRLEDYQRRLDT--SSLVEELRNLDLTKRKMIHEGPLVWK----VNR-----
      HHHHHHHHHHHHHHHHHEEE~~CCCCCCCCCCCCCCCCEEEEEEEEEE~~~~CCC~~~~~
1XCGA AVKQTENRHRLEGYQ-------KRLDATALERA---SNPLAAEFKSLD----LTT-----
      HHHHHHHHHHHHHHH~~~~~~~HHEEECCCCCC~~~CCCCCCCCCCCC~~~~CCC~~~~~
1KZ7A ------------SHL--IAI--TGYDGNLGDLG---K-LLQGSFSVWT----DHKKGELA
      ~~~~~~~~~~~~CCC~~CCC~~CCCCCCHHHHC~~~E~EEEEEEEEEE~~~~EEECCCCC
1FOEA QKIHEE~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      CHHHHH~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1KI1B GVREKENSDRLEWIQ--AHVQCEGLSEQLVFNS---VTNCLGPRKFLHSGKLYKA-----
      HHHHHHHHHHHHHHH~~CEEECCCCCCCCCCCC~~~CCCCCCEEEEEEECCCCCC~~~~~
1UJYA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1AZEA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1UFFA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1OOTA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~


 417  R---------------SKMDRYAFLLDKALLICKRRGDSYDLK----DFVNLHSF-QVRD 456
1F5XA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
2CRHA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1GCPA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1TXDA D---------------KTIDLYTLLLEDILVLLQKQDDRLVLRCTFSPVIKLSTV-LVRQ
      C~~~~~~~~~~~~~~~EEEEEEEEEEEEEEEEEEECCCEEEECCCCCEEECCCEE~EEEE
1XCGA RKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCTFSPVLKLNAV-LIRS
      EEEEEECEEEEECCCCEEEEEEEEEECCEEEEEECCCCEEEECCCCCEEEEECEE~EEEE
1KZ7A R---------------FKPQRHLFLHEKAVLFCKKREENGEGY----EKAPSYSYKQSLN
      C~~~~~~~~~~~~~~~CCCCEEEEEECCEEEEEEEECCCCCCC~~~~CCCEEEEEEEEEC
1FOEA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1KI1B K---------------NNKELYGFLFNDFLLL~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      C~~~~~~~~~~~~~~~CCCCEEEEEECCEEEE~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1UJYA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1AZEA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1UFFA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1OOTA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~


 457  DSSGDRDNKKW-SHMFLLIEDQ--GAQGYELFFKTRELKKKWMEQFEMAISNIYPENATA 513
1F5XA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
2CRHA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1GCPA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1TXDA VAT----NK---ALFVISMSDN--GAQIYELVAQTVSEKTVWQD~~~~~~~~~~~~~~~~
      ECC~~~~CC~~~EEEEEEECCC~~CEEEEEEEECCHHHHHHHHH~~~~~~~~~~~~~~~~
1XCGA VATDKR-------AFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRN~~~~~~~~
      ECCCCC~~~~~~~EEEEEEECCCCCCEEEEEEECCHHHHHHHHHHHHHHHHH~~~~~~~~
1KZ7A TAVGITENVKGDTKKFEIWYNA--REEVYIIQAPTPEIKAAWVNAIRKVLTS~~~~~~~~
      CEEEEECEEECCCEEEEEEECC~~CCEEEEEEECCHHHHHHHHHHHHHHHHH~~~~~~~~
1FOEA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1KI1B ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1UJYA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1AZEA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1UFFA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1OOTA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~


 514  NGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCRASAHKECLGRVPPCGRHGQDFPG 573
1F5XA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
2CRHA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1GCPA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1TXDA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1XCGA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1KZ7A ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1FOEA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1KI1B ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1UJYA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1AZEA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1UFFA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1OOTA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~


 574  TMKKDKLHRRAQDKKRNELGLPKMEVFQEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAE 633
1F5XA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
2CRHA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~KAEAE
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~CCCCC
1GCPA ~~~~~~~~~~~~~~~~~~~~~~KMEVFQEYYGIPPPPGAFGPFLRLNPGDIVELTKAEAE
      ~~~~~~~~~~~~~~~~~~~~~~CEEEEEEECCCCCCCCCCCEEEEEECCEEEEEEEECCC
1TXDA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1XCGA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1KZ7A ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1FOEA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1KI1B ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1UJYA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1AZEA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1UFFA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1OOTA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~


 634  QNWWEGRNTSTNEIGWFPCNRVKPYVHGPPQDLSVHLWYAGPMERAGAESILAN-RSDGT 692
1F5XA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
2CRHA QNWWEG----------------------PPQDLSVHLWYAGPMERAGAESILAN-RSDGT
      CCCCCC~~~~~~~~~~~~~~~~~~~~~~CCCCCCCCCEEECCCCHHHHHHHHCC~CCCCE
1GCPA HNWWEGRNTATNEVGWFPCNRVHPYVH~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      CCEEEEEEECCCEEEEECCCCEEEECC~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1TXDA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1XCGA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1KZ7A ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1FOEA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1KI1B ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1UJYA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1AZEA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1UFFA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1OOTA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~


 693  FLVRQRVKDAAEFAISIKYNVEVKHIKI-M-TAEGLYRITEKKAFRGLTELVEFYQQNSL 750
1F5XA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
2CRHA FLVRQRVKDAAEFAISIKYNVEVKHIKI-M-TAEGLYRITEKKAFRGLTELVEFYQQNSL
      EEEEEECCCCEEEEEEEEECCEEEEEEE~E~ECCCEEECCCCCCCCCHHHHHHHHHCCEE
1GCPA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1TXDA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1XCGA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1KZ7A ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1FOEA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1KI1B ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1UJYA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1AZEA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1UFFA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1OOTA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~


 751  KDCFKSLDTTLQFPFKEPEKRTISRPAVGSTKYFGTAKARYDFCARDRSELSLKEGDIIK 810
1F5XA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
2CRHA KDCFKSLDTTLQFPFKEPEKRTISRSGPSS~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ECCCCCEEEECEEEECCCCCCCCCCCCCCC~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1GCPA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1TXDA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1XCGA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1KZ7A ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1FOEA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1KI1B ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1UJYA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~KARFNFKQTNEDELSVCKGDIIY
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~EECEEEECCCCCEEEECCCEEEE
1AZEA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~AIAKVDFKATADDELSFKRGDILK
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~EEEEEEEECCCCEEEEEEECEEEE
1UFFA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~GSSGY----RALYPFEARNHDEMSFNSGDIIQ
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~CCCCE~~~~EEECEEEECCCCCEEEECCEEEE
1OOTA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~AVALYSFAGEESGDLPFRKGDVIT
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~EEEEEEECCCCCCEEEEECCEEEE


 811  ILNKK-GQQG-WWRGEIYGRVGWFPANYVEEDYSEY 844
1F5XA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
2CRHA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1GCPA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1TXDA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1XCGA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1KZ7A ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1FOEA ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1KI1B ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
      ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
1UJYA VTRVE--EGG-WWEGTLNGRTGWFPSNYVRE~~~~~
      EEECC~~CCC~EEEEECCCCCCEEECCCEEE~~~~~
1AZEA VLNEE-SDQN-WYKAELNGKDGFIPKNYIE~~~~~~
      EEECC~CCCE~EEEEECCCCEEEECCCEEE~~~~~~
1UFFA VDEKTVGEPG-WLYGSFQGNFGWFPCNYVEK~~~~~
      EECCCCCCCC~EEEEECCCCEEEEECCCEEE~~~~~
1OOTA ILKKS-DSQNDWWTGRVNGREGIFPANYVE~~~~~~
      EEEEC~CCCEEEEEEEECCCCEEECCEEEE~~~~~~




PSI-BLAST ALIGNMENTS - 49 SEQUENCES USED BY JNET, TRANSSEC, and PSIPRED
Blast e-value: 0.0
1   >gi|6678555|ref|NP_033526.1| Vav2 oncogene [Mus musculus] >gnl|BL_ORD_ID|181156 Vav-2 protein >gnl|BL_ORD_ID|181156 Vav2 gene product
match: MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNL-SPGSIDLKDINFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLF-DVRDFGKVISAVSRLSLHSIAQSKGIRPFPSEETAENDDDVYRSL-EELA-DEHDLGEDIYDCVPCEDEGDDIYEDIIKVEVQQPMKMGMTEDDKRSCCLL-EIQETEAKYYRTLEDIEKNYMGPLRLVLSPADMAAVFINLEDLIKVHHSF-LRAIDVSMMAGGST-LAKVFLEFKERLLIYGEYCSHMEHAQSTLNQLLAS-REDFRQKVEECTLRVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSADR-PERQQLKEALEAMQDLAMYINEVKRDKETLKKISEFQCSIENLQVKLEEF-GRPKIDGELKVRSIVNHTKQDRYLFLFDKVVIVCKRKGYSYELKEVIELL-FHKMTDDPMHNKDIKKWSYGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFE-MAMSNIKPDKANANHHSFQMYTFDKTTNCKACKMFLRGTFYQGYLCTRCG-VGAHKECLEVIPPCKMSSPADVDAPGAGPGPKMVAVQNYHGNPAPPGKPV-LTFQTGDVIELLRGDPDSPWWEGRLVQTR---KSGYFPSSSVKPCPVDGR-PPTGRPPSREID---YTAYPWF--AGNME--RQQ---TDNL-L---K----SHA-SGT---YLIRE-RPAEAE----RFAI-S-I-K-FNDEV---KHIK--V--VEKDSWIH-ITEAKKF-ESLLE-LVEYYQ---CH--SLKE-SFKQLD-TT-LKFP-YKSRERTTSRASSRSPASCASYNFSFLSPQGLSFAPQ---AP-SAPFWSVFTPRVIGTAVAR-Y--NFAA-RDMRELSLREGD-VVKI-YSRI-GG--DQGW-WKGET-N--GRI-GWFPS-TYVEEE-----------------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 7.84113E-68
2   >gi|34879872|ref|XP_343780.1| similar to faciogenital dysplasia homolog [Rattus norvegicus]
match: ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ERQESVEKLSHTRETSQQLEKGH-RARAPMGPEALGGWGLFPCFVYLMFRQKESLHSRKVSARIPALPELSTAV-GPGAREYRDDTQQLTVQQKVFHIANELLQTEKAYVSRLHLLDQVFCARLL-EEARNRSSFPADVVHGIFSNICSIYCFHQQFLLPELESAWRNGSQLKNGF-LPEAGDQVSPCFYSRDRYPRIGDILQKLAPFLKMYGEYVKNFDRAVELVN-TWTERSTQFKVIIHEVQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLL-KLPHGSPDSKDAQKSLELIATA--AEHSNAAIRKMERMHKL-LKVYEL------LGGE--EDIVSPTKELIKE----GHIL-K-LSA-KNGTT---QDRY--LILFNDRLLYC-VPRLRLL-GQKFS-VRARID-V-DG--MELK-ESSNLN-MP-RTF--LVSGKQRSLELQARTEEEKKDWVQAINSTLLKHEQTLETFKL-LNSTNRDDEDTPPNSPNVD-L--GKRAPTPIRE---KE----VTM-CMRC-QEPFNSITKRRHHC-KACGHVVCGKCS-EF---------------------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 1.40901E-60
3   >gi|39983003|gb|AAR34457.1| epithelial cell transforming 2 [Xenopus laevis]
match: --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFTRETDLT-PFPPRKRPSAEHSLSIGSLLDISNTPESGKSFSDTPKIIKPSKVSTPVPQ-QSARWQVAMELYQTESNYVDILTTIVQLFQLPLEKEGQLGGPILAQEEIK-TIFGSIPDILDVHTNIKGDLEKLMIDWAESKSIGDIILTYSKDLEKIYPP-FVNFFEMSKETIIKCEKQKPRFHAFLKINQSKPECGRQTLVELLIRPVQR-LPSVALLLNDI-KKHTADDNPD----KVLLEKAIDS-LKQVMTYINEDKR-KTEGQKQ-IFDVVYEVDGCPANLLSSHRMLVQ-R-VETIALGEDLCDRGE-QVTL-FLFNDCLEIARKRHKVIGAFKTLHGHTRPPACLKHICL--MLLSQ-IKKVLNVKDTEECHNAFALVVRPPTEQTNQLFSFQLTTEELPKVDWLKML-CRHVAN---------------------------------------------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 2.57155E-57
4   >gi|7329076|gb|AAF59903.1| intersectin 2 long isoform [Homo sapiens]
match: ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ERKR-QGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKEL-IMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLN-GAALLQQKTDEDTDFKE----F-LKKLASDPRCKGMPLSSF-LLKPMQR--ITRYPLLIRSIL-ENTPESHAD----HSSL-K-LALERAEEL-CSQVNEG-VREKENSDRLE-WIQAHVQCEGLAEQLI--FN-S-LT--NCLG-PRK-------LLHS-GKLYKTKS-KELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSS-KSNAQFKMYKTPIFLNEVL-V--KLPTDPSSDEPVFHISH-IDRV-YTLR-TDNINERTAWVQKIKAA--------SE-QYIDTEKKKREKA----------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 1.62563E-56
5   >gi|24660496|ref|NP_729307.1| pebble CG8114-PC [Drosophila melanogaster] >gnl|BL_ORD_ID|230416 CG8114-PC [Drosophila melanogaster]
match: --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LSVSNSLFDCTTSPDKLESDKLLHAEPEASDATPAK-KSMRFNHFMDFYTTESNYVGILDTILNLFKNKLEELAETNDPLLNKSEIK-TIFGNFLPIHEVHQSMLEHLRKLHANWREDCLIGDIIIQHRDELIKAYPP-YVNFFEQMKEQLQYCDREYPRFHAFLKINQTKPECGRQGLQDLMIRPVQR-LPSISLLLNDIL-KHTTSGNAD----HGRLEEALKAIKQVTLHINEDKRR-TESRM--AIFDIFNDIEGCPAHLVSSNRS-FILK-CEVNELSDSLSGRGD-S--LVLYLFSDSIELCKRRSKGFNTAKSPSTAKTHKHLKLISLNTIRLVI-DISDSPRAFGLLLRGDKEKLYTFTISDEETDKSVYVKKLCNQI-----------------------------------------------------------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 8.76065E-56
6   >gi|7504279|pir||T34428 hypothetical protein F55C7.7d - Caenorhabditis elegans >gnl|BL_ORD_ID|392750 Uncoordinated protein 73, isoform d [Caenorhabditis elegans]
match: -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DEKAEDCLPPPM-ENITINNSIDEKDMNEDSVAASDAVEPEVALPAKVEKTPEETARFKRSYV-LMELVETEQDYVKDLTSVVEGY--IGNLNKMDLPADLVGKDKIIFANIVN-ILEFHKT--NFL-KEIE-KCSE----NYEAAGAAFVKYERRL----HTLY-VTYCQNKPKSDYLL-AQDDFEAFFADTKAKLG-H-KV--ALCD-LLIKPV-QRIMKYQLLLKDILKFTE-RAKDKTDTLKKALQVMHVVPKACDDMMQVGR-LQNFDKSLSAQGKLIHQGT-L--QI-SESIAGNVQKPKDR-RIFL-FEQS-AIIAD-----HIPPKKEFGNPTYIFKSQFMVNK------------------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 1.92049E-53
7   >gi|29568789|gb|AAO91668.1| tight junction-associated guanine nucleotide exchange factor isoform B [Canis familiaris]
match: ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RILSQSTDSLNMRNRALSVESLIDEGAEV-IYSELMSDFETDERDFAADSWSLAVDSSFLQQQKKEVMKQQDVIYELIQT-ELHHVRTLKIMTRLFRTGMLEELQLEPGVVQGLFPCVDELSDIHTRFLSQ-LLERRRQALCPGSTRNFVIHRLADLLISQFSGPSAERMRKAYSEFCSRHT-KALKLYKELYARDKRFQ--QFI-RKVTRSAVLKRHGVQECI-LLV-TQR--ITKYPVLINRIL-QHSHGTDEE----RQDL-T-TALGLVKELLSNVDQDV-HELEKGARLQE-IYHRMDPRAQAPVPSKGPFG-R-EE--LLRR-KLIH-D-GC-LLWK-TATGRFKDVLMLLMTDV--LVFLQEKDQKYIFPALDKPSVVS-LQNLIVRDIANQE---KGM-F--LISA--APPEM--------YEV-HTAS-RDD-RSTWVRVIQQSVRVCPSREDFP---LIETEDEAYLRRIKMELQ----
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 2.57703E-46
8   >gi|9845277|ref|NP_063920.1| neuronal guanine nucleotide exchange factor; transforming immortalised mammary epithelial sequence 2 [Mus musculus] >gnl|BL_ORD_ID|61458 guanine nucleotide exchange factor [Mus musculus]
match: -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PEEIRLQEAMFE-LVTSEASYYKSLNLLVSHFMENERLKKILHPSEAHILFSNVLDVMAVSER-FLLELEHRMEENIVISDVCDIVYRY-AADHFSVYITYVSNQTYQERT----------------------PKCK----GLPFSSFLILPFQRITRLKLLVQN-ILKRVEERSEREGTALDA--HKELEMVVKACNEG-VRKMSRTEQMISIQK-KMEFKIKSVP-IISHSRWLLKQGELQQMSGPKTSRTLRTKKLFREIYLFL-FNDLLVICRQIPGDKYQV--FDSAPRGLLRVEELE-DQGQTLANVFILRL-LENADDREATYMLKASSQSEMKRWMTSL-----------------------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 8.09132E-46
9   >gi|31202929|ref|XP_310413.1| ENSANGP00000005626 [Anopheles gambiae] >gnl|BL_ORD_ID|720490 ENSANGP00000005626 [Anopheles gambiae str. PEST]
match: --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DTRTHVVVELFNTEKSYVESLQTIVLKYLNQLK-SPENAGLVDVQTVDEIFFMVPAILNIHERFLEELRRRLDSWDKMQMIGDA-FVDVFSRPVILDTYTSFVNNWNRAKDAIRSARQKCPAFARF-LEAMAREH-KGKL--SLDNLLIKPVQKFPNY----ELIFTRLIKHTDVTHPDQKPLQEA-LKLVHDILMFLNCKEKEALENGQRETALRELE-G-V-IEGMND--LVTPE-RAFLLFDLVSMPSGQVTRKERGFFLFNDLLVITSIKRRSGTIRKTNMTCP-GSVASTLDTNK-------YKYLTKI-SLDDLEIVKSKDEN-VRRI-MKEI-EHLTED---------------------------------------------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 7.20416E-40
10  >gi|4138837|gb|AAD03594.1| phospholipase C-gamma-1a [Xenopus laevis]
match: ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CN-EFEMRLTEPVPQTNAHESKEWY--HASLT--RGQ---AEHM-LM-------RVPRDGA---FLVRKRSEQNS------YAI-S-F-R-AEGKI---KHCR--VIQEGQSVVLG-SSEFDS-----LVDLISYYE-K--H--PLYR-KMK-------LRYP-INEETLEKIGTPDPDYGALYE--------------GR---NP-GFYVEANPMPTFKCSVRAL-F--DYKA-QREDELTFTKNT-IIQN-VEK---Q--EGGW-WRGDC-G--GKKQMWFPA-NYMEEIFS---------------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 7.09451E-39
11  >gi|33146382|dbj|BAC79392.1| transforming gene product TGAT [Homo sapiens]
match: -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSSSPSFNPSDN-SLLSSSSPI-DEMEE--------RKSSSLKRR----HYVLQELVETERDYVRDLGYVVEG-YMALMKEDGVP--DDMKGKDKIVFGNIHQIYDWH-RDFF-LGELEKCLED-PEKLGSLFVKHERRLHMYIAYCQNKPKSEHIVSEYIDTFFEDLKQRLGHR-LQLTDLLIKPVQRIMKYQL-LLKDFLKYSKKASLDTSELERAVEV-MCIV-PRRCNDMM-------------------------------------------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 2.73996E-36
12  >gi|39582132|emb|CAE60809.1| Hypothetical protein CBG04507 [Caenorhabditis briggsae]
match: -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FVAL-YDFHGVGEEQLSLRKGDQVRILGYNKNNEWCEARLYSTRKNDASSQRRLG-EIGWVPSNFIAPYNSLDKYTWY--HGKIS--RSD---SEAV-LGSG--------ITGS---FLVRESETSIG-----QYTI-S-V-R-HDGRVF---HYR--INVDNTERMFI-TQEVK-------------FR-T-LG--ELVH-HHSVHA-DG-LICT-LMYPASKKDKTRGLFSLSPNAPDEWELDRSEIIMHNK---LG-GGQYGDVYEGYWK-----------------------------------------------------------------------------------------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 1.39739E-31
13  >gi|30088972|gb|AAP13499.1| intersectin 1 isoform 7 [Mus musculus]
match: -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-RQGYIHELIVTEENYVNDLQLVTEIFQKPLTESELLTEKEVAMIFVNWKE-LIMCNIKLLKAL-RVRKKMSGEKMPVKM-IGDILSAQLPHMQPYIRFCSC---QLNGAALIQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVT-RYPLIIKN-------------------------------------------------------------------------------------------------------------------------------------------------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 1.15473E-27
14  >gi|37776869|emb|CAE51198.1| src tyrosine kinase [Schistosoma mansoni]
match: -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TIG-DKSSIGNSSCLPNTHQSTNFSPTQQPANFLNNSVAHMRNNPSHNSPQIPT-EGQFVALHDYVKRVDDDLNMTKGQIFNILDNSHCDWWYAECVSTGNRGYV-PKNHL-----AAVTSLESNEWY--FGELK--RIE---AEHY-LQLPGND--H----GS---FLVR-ISESQSS----EYSL-S-VR--EENTV---KHYR--I-----RSRYS-RTDPTLK-RFYISRQL-PFV-N-IQ--QLVN-HYLENQ-SG-LCCR-LGKPCIRPTHPEP------------------------------------------------------------------------------------------------------------------------------------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 2.81974E-27
15  >gi|31238506|ref|XP_319789.1| ENSANGP00000005190 [Anopheles gambiae] >gnl|BL_ORD_ID|1021323 ENSANGP00000005190 [Anopheles gambiae str. PEST]
match: ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VEYY--VACYAYQSAE---AGDL-VFD----------AGE--TIAV---SKKEGD----WWTG-T-IGN-RTGIFPSNYVQK--HEGVSNPIGEA-KTVHLRR-KGEVAQVIAPYE-A-TS--SEQL-SLQRGQ-LI-MIRK-KTDSGWWEGELQAKGRRRQIGWFPATYVKILQGGRNSGRNTP-VSASKVELTETILDKVIAL-Y--PYKA-LNDDELSFEKDD-IISV-LGR---D--EPEW-WRGEL-NGT---TGLFPS-NYV--------------------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 4.38458E-26
16  >gi|31981477|ref|NP_035611.2| src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites [Mus musculus] >gnl|BL_ORD_ID|22857 srm [Mus musculus]
match: -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PAPR-ARLFRALYDFTARCAEELSVSRGDRLYALKEEGDYIFAQRLSGPPSTGLV-PVTYLA---KATPEPPSDQPWY--FSGIS--RAQ---AQQL-LLSPA----N-A-PGA---FLIRPSESSIGG-----YSL-S-V-R-AQAKV---CHYR--ICMAPSGSLY--LQEGQLF-PSLDA-LLAYYK-T-NW--KLIQ-NPLLQP-CI-PQIP-LVQDEWERPRSEFVLRKKLG-----------------------------------------------------------------------------------------------------------------------------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 6.54429E-26
17  >gi|28278414|gb|AAH45386.1| Similar to phosphoinositide-3-kinase, regulatory subunit, polypeptide 3 (p55, gamma) [Danio rerio]
match: --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NGVKEAASGSLQEAEWY--WGDIS--REE---VND--KLR-D----M-P-DGT---FLVRDASTKMQG----DYTL-T-L-R-KGGNN---KLIK--I--YHRDGKYG-FSDPLTF-NSVVE-LISHYR-H--E--SLAQ-YNTKLD-VK-LMYP-VSRYQQDQLVKEDN-----------------------------------------------------------------------------------------------------------------------------------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 7.99753E-25
18  >gi|25141314|ref|NP_491290.2| UNCoordinated locomotion UNC-89, PHarynx Muscle abnormal PHM-1, UNC-89 (unc-89) [Caenorhabditis elegans] >gnl|BL_ORD_ID|690928 Muscle M-line assembly protein unc-89 (Uncoordinated protein 89) >gnl|BL_ORD_ID|690928 Uncoordinated protein 89, isoform a [Caenorhabditis elegans]
match: ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ENVSL-SDEQAALVKRDQVYHELLRSEEEFVSSLRTCVDDYIKVLDDPEVPEAVKK-NREELTLNIPELYNFHANVMLKGLNYYSDDPGKVGQTFVRLEKDFESHVE-FYKQYADTLKL-LEEPEIKRFF-EGLSAKNDAGASSFVDH--VKEIADR--MVQYQNYFKEF-VKYSARAHGS----SKSI-Q-KALELVTTIPQRVHDLE-FTNNLKQHPGD-TGKLGRIIRHDAFQVWEGDE-P-PK--LRYV-FLFRNK-IM-FTEQ-DASTSPPSYTHYSSIRLDKYNIRQHTTDEDTIVLQPQEPGLP-SFRIKPKDFETSEYVRKAW-L--RDIA--EEQEKYAAERD-AIS--MTAT-SEMTASSVDFDMNASDQ----------------------------------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 8.49492E-22
19  >gi|39584583|emb|CAE74661.1| Hypothetical protein CBG22462 [Caenorhabditis briggsae]
match: ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QIVQL-SANLVQLLTNEQTKPAEAQQ-I-GACFLQLRK---PFAQTYGFYFRNIEH-INALTNSAKHEKTMEAALLDIV----K-RMREGGAVVIDGPTAVSRPIQ---RATKYPLFLNEIVKLTPLVHTDHPKLTEAIK-Q-MS--NLGQKMNESKR-RKELTQKYMSDDKQTFGEMLSKMTFHSLKKKSNRFTYRMGSSLGVVKLLR-DTDFDRLVCELDSAERRLVRF--NYMLVIYRKKM-FHETR-VL-M-HKKL-VEPRKKALS-NGEIDQ---QLQPFNHAVKIWAND-----------------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 9.94371E-22
20  >gi|66802|pir||TVFFDS protein-tyrosine kinase (EC 2.7.1.112) src2 - fruit fly  (Drosophila melanogaster) >gnl|BL_ORD_ID|1050776 Dsrc28C protein
match: ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSQEHWWKVKDALGNV-GYIPSNYVQAEALLGLERYEWY--VGYMS--RQR---AES--LLKQG----D-K-EGC---FVVRK-SSTKGL-----YTL-S-----LHTKV---PQSH--V--KH----YH-------------------IK-Q--N--ARCE--YY-------LSE-------------------------------------------------------------------------KHCCET--------IPD-LINY-HR--HNS--------------------------------------------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 2.68387E-21
21  >gi|6679321|ref|NP_032867.1| phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta) [Mus musculus] >gnl|BL_ORD_ID|734381 Phosphatidylinositol 3-kinase regulatory beta subunit (PI3-kinase p85-beta subunit) (PtdIns-3-kinase p85-beta) >gnl|BL_ORD_ID|734381 phosphatidylinositol 3-kinase p85 beta subunit [Mus musculus] >gnl|BL_ORD_ID|734381 Phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta) [Mus musculus]
match: ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YSLMEDEDALPHHEERTWY--VGKIN--RTQ---AEE--MLS-G----K-R-DGT---FLIRE-SSQRGC-----YAC-S-V-V-VDGDT---KHCV--I--YRTATGFG-------------------FA----------E-PYN-------L-Y-------------------------------------------------------------------------GSLKEL----------V-LH---YQ--HASL-VQHN--DALT-VTLAHP----VRAP-----------------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 1.13672E-20
22  >gi|2554754|pdb|1PIC|A Chain A, Phosphatidylinositol 3-Kinase, P85-Alpha Subunit: C-Terminal Sh2 Domain Complexed With A Tyr751 Phosphopeptide From The Pdgf Receptor, Nmr, Minimized Mean Structure >gnl|BL_ORD_ID|882033 Chain A, Phosphatidylinositol 3-Kinase, P85-Alpha Subunit: C-Terminal Sh2 Domain Complexed With A Tyr751 Phosphopeptide From The Pdgf Receptor, Crystal Structure At 1.79 A
match: --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIPHHDEKTWN--VGSSN--RNK---AEN--LLR-G----K-R-DGT---FLVRE-SSKQGC-----YAC-S-V-V-VDGEV---KHCV--I--NKTATGYG-------------------FA----------E-PYN-------L-Y-------------------------------------------------------------------------SSLKEL----------V-LH---YQ--HTSL-VQHN--DSLN-VTLAYPV--YAQQRR----------------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 2.66517E-20
23  >gi|17137488|ref|NP_477322.1| Dynamin associated protein 160 CG1099-PA [Drosophila melanogaster] >gnl|BL_ORD_ID|373171 CG1099-PA [Drosophila melanogaster]
match: -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-Q-INT-QSKTQSSEPAES--YSRPMSRTSSM-TPGMRAK-RSEIAQVIAPYE-A-TS--TEQL-SLTRGQ-LI-MIRK-KTDSGWWEGELQAKGRRRQIGWFPATYVKVLQGGRNSGRNTP-VSGSRIEMTEQILDKVIAL-Y--PYKA-QNDDELSFDKDD-IISV-LGRD-----EPEW-WRGEL-N--G-LSGLFPS-NYV--------------------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 1.99078E-19
24  >gi|21745353|gb|AAM77354.1| c-Cbl associated protein CAP [Mus musculus]
match: ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AKFDFKAQTLK-ELPLQKGDVVYIYRQID-QNWY--EGEHHGRVGIFPRTYIE-LLPPAEK--AQPRKLA--PVQVLE------------YGE-A-IAK-FNFN--GDTQVE--MSFRKGERITL-LRQVDEN----------WYE----G--RIPG-TSRQGI-FP-ITY----VDVLKRPLVKTPVDYIDLPYSSSPSRSATVSPQQPQAQQR-RVTPDRSQPSLDLCSYQAL-Y--SYVP-QNDDELELRDGD-IVDV-MEK-----CDDGW-FVGTS-RRTRQF-GTFPG-NYVKPLY----------------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 1.57647E-18
25  >gi|39841043|ref|NP_950187.1| rai-like protein RaLP [Mus musculus] >gnl|BL_ORD_ID|999630 rai-like protein RaLP [Mus musculus]
match: ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RCEKLCYLPGNSTCSGVYKNCMGRSRPIGIPHERAGQGDTPSLRHFW-RVDLFDDPCYVNTQALQSMHSYAGNQSSALPQGSPWHLGKAPETVQPGAT-AKPGSALALPHIRQQLWDEECF--HGKLS--RGA---AEKL-LVK----------DGD---FLVRE-SVTSPG----QFVL-SGLQGGQAKHLLLVDPEGK-V--RTKDHVFDNVGHLIKYHMDNNLPIISSGS-E-VR---LKQ-PIRKYD-NTGLLPP-K------------------------------------------------------------------------------------------------------------------------------------------------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 2.66749E-17
26  >gi|189979|gb|AAA60098.1| protein kinase C alpha-polypeptide
match: ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DTDDPRSKHKFKIHTYGSPT-FCDHCGSLLYGLIHQGMKCDTC----DMNVHK------QCVINVPSLCGM-DHTEKRGRIYLKAEVADEKLHVTVRDAKNLIPMD-PNGLSDPYVKLK-------LIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVEIWD-WDRTTRNDFMGSLSFGVSELMKMPASGWYKL--LNQEEGE-YYNV---------------------------------------------------------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 1.83107E-16
27  >gi|31227203|ref|XP_317844.1| ENSANGP00000014209 [Anopheles gambiae] >gnl|BL_ORD_ID|382220 ENSANGP00000014209 [Anopheles gambiae str. PEST]
match: -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLLTESWY--HGSIS--RAQ---SEH--LLK--------N-DGD---FLVRESAGTQG-----QYVL-T-G-M-QNNSP---KHLL--L--IDPEGIVR-TKDRVFD-SISHL-IN--FH-W-TN--SLPI-ISAESA-LL-LRHP-ILRTT--------------------------------------------------------------------------------------------------------------------------------------------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 2.02389E-16
28  >gi|13384594|ref|NP_002730.1| protein kinase C, gamma; Protein kinase C, gamma polypeptide [Homo sapiens] >gnl|BL_ORD_ID|66628 Protein kinase C, gamma type (PKC-gamma) >gnl|BL_ORD_ID|66628 protein kinase C (EC 2.7.1.-) gamma - human >gnl|BL_ORD_ID|66628 protein kinase C gamma [Homo sapiens] >gnl|BL_ORD_ID|66628 Protein kinase C, gamma [Homo sapiens]
match: ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QTDDPRNKHKFRLHSYSSPT-FCDHCGSLLYGLVHQGMKCSCC----EMNV-------HRRCVRSVPSLCG-VDHTERRGRLQL--EIRAPTADEIHVTVG-------EARNLIPMDPNGLS-DPYVKLKLIPDPRNLTKQKTRTVKATLNPVWNETFVFNLKPGDVERRLSV-EVWDWDRTSRNDFMGAMSFGVSELLKAPVDG-----------------------------------------------------------------------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 3.72146E-16
29  >gi|32451916|gb|AAH54619.1| Unknown (protein for MGC:64107) [Danio rerio]
match: -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VVTSLTAELKKLAKQGWY--WGPIT--RWE---AEE--KLT-N----L-P-DGS---FLVRD-SSDDR------YLL-S-L-S-FRSQT---KT-------LHTR-----------------------IE-H--S--NG-----S-------FSF-------------------------------------------------------------------------YEQPDIE----G-HVSI-VD------------------------------------------------------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 1.101E-15
30  >gi|28828435|gb|AAO51053.1| similar to Y56A3A.13.p [Caenorhabditis elegans] [Dictyostelium discoideum]
match: ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y--LQAKALYD-------------------YN-G--E--NDGD-----------LSF-------------------------------------------------------------------------REG-DI--------ITI-LDQS-DP--DG-W-WQGSL-PT-GE-QGFFPS-NFVQQ------------------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 1.6044E-15
31  >gi|20149738|ref|NP_619598.1| Nck, Ash and phospholipase C binding protein; SH2 domain containing SOCS box protein SOCS7 [Mus musculus] >gnl|BL_ORD_ID|644994 Suppressor of cytokine signaling 7 (SOCS-7) >gnl|BL_ORD_ID|644994 SH2 domain containing SOCS box protein SOCS7 [Mus musculus]
match: ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RELEKCGWY--WGPMN--WED---AEMK-L--------KGKPDGS---FLVRDSSDPR-------YIL-S-L-S-FRSQ-GITHHTR--ME--HYRGTFS-LWCHPKF-EDRCQSVVEFIK-R--A--IMHS-KNGKFL-YF-LRSR-VPGLPPTPVQLLYPVSRFSNVKSLQHLCRFRIRQLVR---ID-HI-PDLPLPKPLISYIRKF-Y--YYDP-QEEVYLSLKEAQ-LISK-QKQE-VE--P----------------------------------------------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 7.14317E-14
32  >gi|34867551|ref|XP_221672.2| similar to invasion inducing protein [Rattus norvegicus]
match: -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLSDADKLRKVICELLETERT-YVKDLNCLMERYLKPLQKETFL-TQDELDVLFGNL--TE-M-VEFQVEFL-KTLEDGVR---LVPDLEKLEKV----D-QF-KKVLFSLGGSFLYYADRFK-LYSAFCASHTKVPKVLV---KAKTDTAFKAFL-D-AQ--NPRQ-QHSSTL-ESYLIKP-IQRVLKYPLLLRELFALTDAESEEHYHLDVAIKTMNKVASHI-NEMQKIHEEFGAVFDQLIA-E--QTGEKKEKRNLKFSRVR-NIAS-GKRE-LDLAFADPK-NGRWLLK-RRIRGTYNAGKIVESWDRQVADLSMGD------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 1.67194E-13
33  >gi|34851915|ref|XP_226572.2| similar to Mixed lineage kinase 4 [Rattus norvegicus]
match: -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MWAALYD-------------------YE-A--R--GEDE-----------LSL-------------------------------------------------------------------------KRGQLVE------VLSQ-DAAV-SG--DEGW-WAGQV-Q---RRLGIFPA-SYV--------------------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 2.6473E-13
34  >gi|27777655|ref|NP_079255.2| MCF.2 cell line derived transforming sequence-like; MCF2 transforming sequence-like protein; guanine nucleotide exchange factor DBS; DBL's big sister [Homo sapiens] >gnl|BL_ORD_ID|735080 MCF.2 cell line derived transforming sequence-like [Homo sapiens] >gnl|BL_ORD_ID|735080 MCF.2 cell line derived transforming sequence-like [Homo sapiens]
match: ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSELLDTERAYVEELLCVLE-GYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNRIFLRELENYTD-CPELVGRCFLERMEDFQIYEKY-CQNKPRSESLWRQCSDCP-FFQECQR--KLDHKLSLDSYLLK--PVQRIT----KYQL-L-LKEMLKYSRNCEGAED--LQEA-LSSILG-ILKAVND-SMHLIAITGYDG-N-LG--DLGK-LLMQGS-FS-VWTD-HKRGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYE-KAPSYSYKQSLNMAAVGIT-E--NVKGDAKKFEIWYNARE-EVYI-VQAP-TPEIKAAW---------VNEIRKVLTS------------------------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 3.26267E-13
35  >gi|2961227|gb|AAC98089.1| myosin IC heavy chain [Acanthamoeba castellanii]
match: -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QARALYD-------------------FA-A--E--NPDE-----------LTF-------------------------------------------------------------------------NEGA-V--------VTV-INK---S--NPDW-WEGEL-N--GQ-RGVFPA-SYVE-------------------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 8.50809E-13
36  >gi|22204259|emb|CAD43428.1| SI:dZ173A8.1.1 (novel protein similar to human intersectin (SH3 domain protein, ITSN1)) [Danio rerio]
match: --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YVAMYT-------------------YE----S--NEQG-D---------LTF-------------------------------------------------------------------------QQG-DV--------ITV-TKK------EGDW-WTGTV--S-GK-IGVFPS-NYVKPKESE--------------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 1.05805E-12
37  >gi|34862389|ref|XP_234942.2| similar to myosin-1F-like protein [Rattus norvegicus]
match: ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MQRKRSIGQRP---VP-GVGRPKPQPRTHGPRCRAL-Y--QYIG-QDVDELSFNVNE-VIEI-L--M-ED--SSGW-WKGRL-H--GQ-EGLFPG-NYVEKI-----------------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 2.02898E-11
38  >gi|26332631|dbj|BAC30033.1| unnamed protein product [Mus musculus]
match: --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDELELKVGDIIEVVGEV-EEGWWEGVLNGKTGMFPSN--F--IKELSGESDELGISQDE-QLSKSRP--EGFLPAS--LLPFPAHGAKGKT----TFEG-T-ILY-RAAPGKTEGHRR--YYSLRETTGSE-SDGGDSS-STKSEGANGTMA-T-AA--IQPK-KVKGVG-FG-DIFK-DKPIKLRPRSIEVENDFLPVEKT---IGKKLPPATST---PD-PSKTEMDSRTKTKDYCKVI-F--PYEA-QNDDELTIKEGD-IVTL-INKD-CI--DVGW-WEGEL-N--GR-RGVFPD-NFVK-------------------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 5.42509E-11
39  >gi|4505347|ref|NP_003572.1| NCK adaptor protein 2 [Homo sapiens] >gnl|BL_ORD_ID|890170 SH2/SH3 adaptor protein NCK-beta [Homo sapiens]
match: ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WDYTAQQDQELDIKKVNERLWL-LDDSKTWWRVR-NAANRT-GYVPSNY--VERKNSLKKGSLVKNLKDTLGL----GKTR-R-KTSARDASPTPSTDAE--Y-PANGSGADR-IYDLNIP-AF----VKFAYV-A-ER--EDEL-SLVKGS-RV-TVME-KCSDGWWRGSYNGQIGWFPSNYVLEEVDEAAAESPSFLSLRK-GASLSNGQGSRVLHVVQTL-Y--PFSSVTE-EELNFEKGE-TMEV-IEKP-EN--DPEW-WKCK--NARGQV-GLVPK-NYV--------------------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 2.60683E-10
40  >gi|22711859|gb|AAN04043.2| Bruton's tyrosine kinase [Gallus gallus]
match: ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RKTKKPLPPTPEEDTMVMKP-LPPEPAPSAAGEMKKVVAL-Y--NYVPM-NVQDLQLQKGE-DYLI-LEE-----SHLPW-WKAR--DKNGR-EGYIPS-NYVTATSNSLEIYEWY-------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 3.49092E-10
41  >gi|38076336|ref|XP_147847.3| similar to mKIAA1112 protein [Mus musculus]
match: -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CAEAL-W--DHVT-MDDQELGFKAGD-VIQV-LEA---S--NKDW-WWGR--NEDKEA--WFPA-SFVRLRVNQEELPE---------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 1.12318E-6
42  >gi|34875668|ref|XP_237115.2| similar to SH2/SH3 adaptor protein [Rattus norvegicus]
match: ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LSFEKGETMEVIEKPENDPEWWKCKNARGQVGLV-PKNYVVVLSDGPALHPTHTPQISYTGPSASGRFAGREWYYGNVTRHQAEC-ALNERGVEGDFLIRDSESSPS-----DFSV-S-LKASGRNKHFKVQLVDS-VYCI-GQRRFHSMDELVEHYKK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 3.86302E-6
43  >gi|17137478|ref|NP_477316.1| CG9635-PA [Drosophila melanogaster] >gnl|BL_ORD_ID|447328 CG9635-PC [Drosophila melanogaster] >gnl|BL_ORD_ID|447328 CG9635-PA [Drosophila melanogaster] >gnl|BL_ORD_ID|447328 CG9635-PC [Drosophila melanogaster]
match: ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ERVHHFVSRDKSFKSRIMGKNRKMNV-RGHPLVLRQYYEVTHCNHCQTI----IWGVSPQGYHCTDCKLNIHRQCSK-VVDESCPGPLPQAKRLAHNDK--ISKFMGKIRPR-TSDVIGNEK----------------------------------------------------------------------------------------------------------------------------------------------------------------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 6.6375E-6
44  >gi|34871025|ref|XP_342917.1| similar to CD2-associated protein [Rattus norvegicus]
match: ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AQTED-ELSLAPGDVIQQVCAVPARGWL--LGELRGRRGLFP---KR-LVQE--I--PEALRG------VTESRPR--------FPR-R-RGHPIDSQ-SPQRWCK--VNFN-----YS-PEQADEL-KLQIGEILEVIK-E-IE--DGWW-LGKKNG-QL-GAFP-SNFVELLDSGPPSLGNTDMPS-----IIPTSQRPPKLSNLTY-DSPPDYLRTVSCPETCRVL-F--DYQP-EAPDELALQKGD-LVKV-LRKT-TE--DKGW-WEGEC-Q--GR-RGVFPD-NFV--------------------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 1.7934E-5
45  >gi|21703900|ref|NP_663427.1| RAS p21 protein activator 1; p120-rasGAP; GTPase-activating protein [Mus musculus] >gnl|BL_ORD_ID|134600 RAS p21 protein activator 1 [Mus musculus]
match: ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MCGDYYIGGRRFSSLSDLIGYYSHVSCLLKGEKL-LYPVAPPEPVEDRRRVRAI-L--PYTKVPDTDEISFLKGD-MFIV-HNEL-----EDGWMWVTNL-RTDEQ--GLIVE-DLVEE------------------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 1.10452E-4
46  >gi|5729856|ref|NP_006604.1| GRB2-related adaptor protein; growth factor receptor-bound protein 2-related adaptor protein [Homo sapiens] >gnl|BL_ORD_ID|1044707 GRB2-related adaptor protein >gnl|BL_ORD_ID|1044707 Grb2-related adaptor protein >gnl|BL_ORD_ID|1044707 Unknown (protein for MGC:64880) [Homo sapiens]
match: --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RTTTIAKKRQIFLRDEEPLLK-------------------------------SPGACFAQAQ-F--DFSA-QDPSQLSFRRGD-IIEV-LER---P--DPHW-WRGR---SCGRV-GFFPR-SYVQPV-----------------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 5.34962E-4
47  >gi|32451660|gb|AAH54597.1| Unknown (protein for MGC:64026) [Danio rerio]
match: ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AKAL-L--DFER-HDDDELGFRKND-IITI-ISQK-DE--HC---WVGEL-NGL---RGWFPA-KFVE-------------------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 5.96252E-4
48  >gi|2144421|pir||TVHUHC protein-tyrosine kinase (EC 2.7.1.112) hck - human >gnl|BL_ORD_ID|847513 protein-tyrosine kinase >gnl|BL_ORD_ID|847513 Unknown (protein for MGC:22922) [Homo sapiens]
match: -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LSFQKGDQMVVLEES-GEWWKARSLATRKEGYI-PSNYV-----ARVDSLETEEWF-FKG-IS--RKD---AERQ-LLAPGNML------GS---FMIRDSETTKGS-----YSL-S-VRDYDPRQGDTVKHYK--IRTLDNGGFY--------------ISPRSTFS-T-LQ--ELVD-HYKKGN-DG-LCQK--------------------------------------------------------------------------------------------------------------------------------------------------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

Blast e-value: 8.05158E-4
49  >gi|18104991|ref|NP_536858.1| protein tyrosine phosphatase, non-receptor type 6 isoform 2; protein-tyrosine phosphatase 1C; hematopoietic cell phophatase; hematopoietic cell protein-tyrosine phosphatase; 70 kda SHP-1L protein [Homo sapiens] >gnl|BL_ORD_ID|100433 protein-tyrosine phosphatase 1C [Homo sapiens] >gnl|BL_ORD_ID|100433 Protein tyrosine phosphatase, non-receptor type 6, isoform 2 [Homo sapiens] >gnl|BL_ORD_ID|100433 Protein tyrosine phosphatase, non-receptor type 6, isoform 2 [Homo sapiens] >gnl|BL_ORD_ID|100433 protein tyrosine phosphatase, non-receptor type 6 [Homo sapiens] >gnl|BL_ORD_ID|100433 protein tyrosine phosphatase SHP-1 [Homo sapiens] >gnl|BL_ORD_ID|100433 protein Tyr phosphatase
match: -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPTSERWY--HGHMSGGQ-----AETL-LQAKG--------EPW--TFLVRE-SLSQPG----DFVL-S-VLS-DQPKAGPGSPLR--VT--------H-IKVMCEG-GRYTVGGLETFD-S-LT--DLVE-HFKKTG-IE-E-----------------------------------------------------------------------------------------------------------------------------------------------------
query: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNL-LPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLF-DVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQID-DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLR-EIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-LKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA-REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHY-GRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH-SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFE-MAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR-ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF-QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWF-PCNRVKPYVHGPPQDLSVHLWY--AGPME--RAG---AES--ILA-N----R-S-DGT---FLVRQ-RVKDAA----EFAI-S-I-K-YNVEV---KHIK--I--MTAEGLYR-ITEKKAF-RGLTE-LVEFYQ-Q--N--SLKD-CFKSLD-TT-LQFP-FKEPEKRTISRPAVG-----S-------------------------------TKYFGTAKAR-Y--DFCA-RDRSELSLKEGD-IIKI-LNKK-GQ--Q-GW-WRGEI---YGRV-GWFPA-NYVEEDYSEY-------------

                        

3D Structures:
Click below to view the 3D structure of a PDB homolog related to your protein.
  • 1F5XA (e-value = 1.0E-105) - Matches to residues 169 - 423
  • 2CRHA (e-value = 5.0E-65) - Matches to residues 716 - 870
  • 1GCPA (e-value = 8.0E-34) - Matches to residues 683 - 747
  • 1TXDA (e-value = 6.0E-17) - Matches to residues 194 - 584
  • 1XCGA (e-value = 2.0E-13) - Matches to residues 199 - 592
  • 1KZ7A (e-value = 7.0E-12) - Matches to residues 199 - 592
  • 1FOEA (e-value = 5.0E-11) - Matches to residues 188 - 426
  • 1KI1B (e-value = 1.0E-9) - Matches to residues 194 - 512
  • 1UJYA (e-value = 7.0E-9) - Matches to residues 878 - 931
  • 1AZEA (e-value = 1.0E-8) - Matches to residues 877 - 930
  • 1UFFA (e-value = 5.0E-8) - Matches to residues 869 - 931
  • 1OOTA (e-value = 6.0E-8) - Matches to residues 877 - 930